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Reductions in infarct size are abolished by inhibiting NADPH Oxidase (with pre-exercise treatment of apocynin or Vas2870) during exercise. Inhibition of mitochondrial ROS during exercise (with pre-exercise administration of TEMPO or the mitochondria-targeting peptide Bendavia) had no effect on exercise cardioprotection. Figure reproduced from Frasier et al., Cardiovascular Research 2013, with permission (pending).
