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. 2015 Jun 25;13(2):1559325815592606. doi: 10.1177/1559325815592606

Figure 3.

Figure 3.

Inhibition of PI3K activity attenuated the hormetic and neuroprotective effects of camptothecin (CPT) at low doses. A, PC12 cells were treated with 2.5 μmol/L LY294002 (a PI3K inhibitor) alone or in combination with 0.11 and 0.22 μmol/L CPT for 24 hours. B, PC12 cells were pretreated with or without LY294002 for 2 hours. Cells were then treated with 2 μmol/L H2O2 alone or in combination with 0.05, 0.11, and 0.22 μmol/L CPT for 24 hours. Cell viability was determined by MTT assay as described in Materials and Methods section. Data are represented as means ± SD of 3 to 5 independent experiments. **P < .01, compared to CPT-treated groups.