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Hybrid regimen and reverse hybrid regimen. Hybrid therapy (a 2-step 2-phase therapy) consists of a proton pump inhibitor and amoxicillin (backbone drugs) for 10 to 14 days, with addition of clarithromycin and metronidazole for the final 7 days; reverse hybrid therapy (an 1-step 2-phase therapy) consists of a proton pump inhibitor and amoxicillin for 10 to 14 days, with addition of clarithromycin and metronidazole for the first 7 days.
