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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Mol Microbiol. 2015 Jul 17;97(6):1097–1113. doi: 10.1111/mmi.13088

Figure 6. Proposed mechanisms for environmental activation of Rgg2/3 signaling.

Figure 6

Rgg2 (blue) and Rgg3 (green) are transcription factors that control expression of target promoters in response to peptide pheromones (center panel). Induction of this regulatory pathway generates biofilm production and lysozyme resistance. (Right panel) The metal-dependent transcriptional regulator MtsR (red) represses transcription of shp3 until iron or manganese concentrations are limiting, whereupon repression is relieved and SHP3 pheromones are generated to initiate the positive feedback loop of SHP production. (Left panel) Import of mannose through PtsABCD leads to enhanced expression of Rgg2 by an unknown mechanism, but we suggest includes an additional transcriptional regulator modified by transport of mannose.