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. 2015 Dec 7;211(5):1057–1075. doi: 10.1083/jcb.201404147

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© 2015 Kumar et al.

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Figure 1. — K8/K18 filaments sustain normal development of intestine simple epithelia until birth in KtyI^−/− mice. (A) Immunofluorescence analysis of Krt8, Krt18, and Krt19 in embryonic intestine of KtyI^+/+ and KtyI^−/− E18.5 embryos. Bars, 20 µm. (B) Immunofluorescence of actin (phalloidin), E-cadherin (E-Cad), and desmoplakin (DSP) showed unaltered localization in E18.5 KtyI^+/+ and KtyI^−/− embryos. Bars, 20 µm. (C) Western blotting of Krt8, Krt18, Krt19, and α-tubulin as loading control of intestine of KtyI^+/+ and KtyI^−/− E18.5 embryos. (D) Unaltered proliferation rate in the intestine of E18.5 KtyI^+/+ and KtyI^−/− embryos based on Ki-67 labeling. Related to Fig. S2 D. (E) Hematoxylin/eosin and periodic acid–Schiff (PAS) stained sections of intestine from E18.5 KtyI^+/+ and KtyI^−/− embryos revealing normal morphology. (F) Expression of simple epithelial keratins in different organs of WTs and KtyI^−/− and KtyII^−/−_K8 E18.5 embryos.