Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Dec 7;211(5):1057–1075. doi: 10.1083/jcb.201404147

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 Kumar et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 4. — Electron microscopy analysis of skin from KtyI^+/+ and KtyI^−/− E18.5 embryos depicting structural changes. (A and B) Hemidesmosomes (black arrowheads) of the stratum basale are readily detectable in KtyI^−/− animals. Note, however, the absence of keratin filaments (KF) and occurrence of cytolysis in the basal cell layer of KtyI^−/− epidermis (B, asterisk). Insets show higher magnification of hemidesmosomes together with the adjacent basal lamina (BL). (E and F) Desmosomes (black arrows) in the suprabasal layers of KtyI^−/− epidermis are smaller and less frequent compared with KtyI^+/+. Note the wide intercellular space in the stratum spinosum of KtyI^−/− epidermis and intramitochondrial inclusions (white arrowheads). Insets in E and F show higher magnification of desmosomes. (G and H) Corneodesmosomes (white arrows) in the stratum corneum can be easily distinguished in KtyI^−/− animals. Insets show higher magnification of corneodesmosomes. Bars: (insets) 100 nm; (A, B, and E–H) 1 µm; (C and D) 5 µm.