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. 2015 Dec 7;211(5):1057–1075. doi: 10.1083/jcb.201404147

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© 2015 Kumar et al.

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Figure 8. — CE proteome profile is keratin dependent. Grouping of CE constituents according to function in the presence and absence of type I and type II keratins. (A) CE initiation and reinforcement. Decrease in desmoglein-1 (underlined in blue), but increase in corneodesmosome and CE initiation and reinforcement proteins in KtyI^−/− and KtyII^−/−_K8 compare d with WT. Less transglutaminase (tgm-1 and -3) and arachidonate 12-lipoxygenase (alox12b) are cross-linked in both KtyI^−/− and KtyII^−/−_K8 compared with WT. (B) Except repetin, fewer major CE structural proteins are cross-linked in both KO strains compared with WT. (C) Cross-linking of proteases and protease inhibitors involved in terminal differentiation and barrier function is similarly changed in KtyI^−/− and KtyII^−/−_K8 compared with WTs. Cathepsin-D (Ctsd) and Spink5 are underlined in orange and are only altered in KtyII^−/−_K8. (D) Enhanced cross-linking of alarmins in KtyI^−/− and KtyII^−/−_K8 compared with WTs (red hash marks hspa2, which is upregulated in KtyII^−/−_K8 only). *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001.