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. 2015 Dec 7;211(5):1077–1091. doi: 10.1083/jcb.201502036

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© 2015 Stark et al.

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Figure 6. — Ephrin-A3^−/− diaphragm muscle displays a phenotype intermediate between TA and soleus muscles. (A) As noted in hindlimb muscles, ephrin-A3 expression is detected on all MyHC-I^+ve myofibers in the diaphragm; in sections taken as indicated in the cartoon at right, MyHC-I is expressed by 14% of myofibers scored, all of which also express ephrin-A3. Bars: (top) 400 µm; (bottom) 100 µm. (B) Equivalent sections of wild-type and ephrin-A3^−/− adult diaphragm show a reduction, but not loss, of slow myofibers. Bars, 500 μm. (C) Representation of the plane of section in A and B and quantification of muscle fiber types and ephrin-A3 expression in WT diaphragm. (D) Quantification of Type I fibers through the same plane of section in wild-type and ephrin-A3^−/− adult diaphragm; error bars represent SEM. WT, wild type. ***, P < 0.001.