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Numbers of mice bearing MDA-MB-231–LM2-4175 xenografts that had lung metastases after treatment with vehicle (control) or selumetinib (50 mg/kg mouse body weight) daily for 3 weeks.
| Weeks of treatment | Group of treatment | Number of mice with metastatic tumors | Incidence of lung metastasis |
|---|---|---|---|
| Week 1 | Vehicle | 9/15 | 60 |
| Selumetinib | 3/14 | 21 | |
|
| |||
| Week 2 | Vehicle | 9/14 | 64 |
| Selumetinib | 3/13 | 23 | |
|
| |||
| Week 3 | Vehicle | 9/14 | 64 |
| Selumetinib | 5/13 | 38 | |
