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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Mol Cancer Ther. 2015 Oct 6;14(12):2789–2796. doi: 10.1158/1535-7163.MCT-15-0532

Figure 2.

Figure 2

Stimulation of PBMC from 10 donors with LMB-T20 and SS1P show a decrease in T cell activation. PBMC from 10 naïve donors were stimulated with either SS1P or LMB-T20. After 14 days of in vitro expansion cells that were re-stimulated with either 111 peptides spanning the sequence of PE38 or 76 peptides spanning the sequence of LMB-T20. T cell activation was detected using IL-2 ELISpot. All positive peptides were assayed twice for each PBMC sample and each assay was run in triplicate. Response strength is shown in the SFC ladder on the right. Black stars represent peptides that were deleted in LMB-T20 and red stars represent peptides that are different from wild type.