Fig. 4.
Effects of photobiomodulation on IL-6 (a), COX-2 (b) and TNF-α(c) production. Protein concentration in the samples was quantified 24 h and 72 h after irradiation procedures and is presented as the mean ± SE. Significance between groups was determined using Fisher's exact test. Control: no laser, no activation; activated: LPS + IFN-γ stimulation; activated + 660 nm: LPS + IFN-γ stimulation + 660 nm laser irradiation; activated + 780 nm: LPS + IFN-γ stimulation + 780 nm laser irradiation. n = 3 independent experiments for each group. Both lasers were able to reduce TNF-α and COX-2 production, 660 nm laser parameters resulted in an up-regulation of IL-6 production.