. Author manuscript; available in PMC: 2016 Dec 1.

Published in final edited form as: Mol Cancer Ther. 2015 Oct 29;14(12):2874–2886. doi: 10.1158/1535-7163.MCT-15-0274

Table 1.

Correlation of Enzyme Activity to Protein Level and mRNA Expression Level of CYP enzymes.

Isoforms	Activity vs Protein				Activity vs mRNA				Protein vs mRNA
	Pericarcinomatous		Tumor		Pericarcinomatous		Tumor		Pericarcinomatous		Tumor
	r²^a	slope^b	r²	slope	r²	slope	r²	slope	r²	slope	r²	slope
CYP3A4	0.804*	35.6	0.728*	25.5	0.492*	4.5	0.426	23.1	0.690*	0.12	0.590*	0.85
CYP2D6	0.928*	3.0	0.767*	1.7	< 0.100	-	0.670*	0.02	0.259	0.03	0.827*	0.01
CYP2C9	0.799*	4.6	0.851*	4.6	0.204	2.9	0.565*	2.6	0.543*	0.66	0.593*	0.49
CYP2C8	0.792*	1.0	0.907*	1.5	0.458	0.6	0.712*	1.4	0.584*	0.59	0.578*	0.88
CYP2E1	0.727*	32.2	0.687*	33.1	< 0.100	-	0.491*	10.2	< 0.100	0.11	0.564*	0.31
CYP2A6	0.917*	30.3	0.828*	29.2	0.337	3.2	0.269	4.9	0.412	0.11	0.138	0.17
CYP1A2	0.688*	13.4	0.544*	13.7	0.590*	4.3	0.577*	4.8	0.477*	0.29	0.482	0.40

r² is Pearson’s or Spearman’s correlation coefficient, and “*” denotes statistical significance of association (p < 0.05).

slope of regression line.