Table 1.
Isoforms | Activity vs Protein
|
Activity vs mRNA
|
Protein vs mRNA
|
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Pericarcinomatous
|
Tumor
|
Pericarcinomatous
|
Tumor
|
Pericarcinomatous
|
Tumor
|
|||||||
r2a | slopeb | r2 | slope | r2 | slope | r2 | slope | r2 | slope | r2 | slope | |
CYP3A4 | 0.804* | 35.6 | 0.728* | 25.5 | 0.492* | 4.5 | 0.426 | 23.1 | 0.690* | 0.12 | 0.590* | 0.85 |
CYP2D6 | 0.928* | 3.0 | 0.767* | 1.7 | < 0.100 | - | 0.670* | 0.02 | 0.259 | 0.03 | 0.827* | 0.01 |
CYP2C9 | 0.799* | 4.6 | 0.851* | 4.6 | 0.204 | 2.9 | 0.565* | 2.6 | 0.543* | 0.66 | 0.593* | 0.49 |
CYP2C8 | 0.792* | 1.0 | 0.907* | 1.5 | 0.458 | 0.6 | 0.712* | 1.4 | 0.584* | 0.59 | 0.578* | 0.88 |
CYP2E1 | 0.727* | 32.2 | 0.687* | 33.1 | < 0.100 | - | 0.491* | 10.2 | < 0.100 | 0.11 | 0.564* | 0.31 |
CYP2A6 | 0.917* | 30.3 | 0.828* | 29.2 | 0.337 | 3.2 | 0.269 | 4.9 | 0.412 | 0.11 | 0.138 | 0.17 |
CYP1A2 | 0.688* | 13.4 | 0.544* | 13.7 | 0.590* | 4.3 | 0.577* | 4.8 | 0.477* | 0.29 | 0.482 | 0.40 |
r2 is Pearson’s or Spearman’s correlation coefficient, and “*” denotes statistical significance of association (p < 0.05).
slope of regression line.