Table 2.
Histopathological features and HCC molecular subclasses in the training and validation sets.
| Training Set (96 HCC tumors) | Validation Set (99 HCC tumors) | P value | |
|---|---|---|---|
| Histopathological feature | |||
| Architectural pattern | |||
| Microtrabecular | 53 (55%) | 53 (54%) | 0.89 |
| Macrotrabecular/compact | 38 (40%) | 39 (39%) | 1.00 |
| Pseudoglandular | 31 (32%) | 14 (14%) | 0.004 |
| Cytological variant | |||
| SH-HCC | 19 (20%) | 17 (17%) | 0.71 |
| Clear cell | 23 (24%) | 7 (7%) | 0.001 |
| Fatty change | 17 (18%) | 10 (10%) | 0.15 |
| Edmondson-Steiner grade | |||
| I | 12 (13%) | 21 (21%) | 0.29 |
| II | 66 (69%) | 62 (63%) | |
| III | 17 (18%) | 16 (16%) | |
| IV | 1 (1%) | 0 (0%) | |
| Immune cell infiltrate score* | |||
| 0 | 15 (16%) | 18 (18%) | 0.08 |
| 1 | 42 (44%) | 28 (28%) | |
| 2 | 39 (41%) | 53 (54%) | |
| Microvascular invasion | 9 (9%) | 16 (16%) | 0.20 |
| Molecular subclass | |||
| S1 | 30 (31%) | 30 (30%) | 0.46 |
| S2 | 27 (28%) | 21 (21%) | |
| S3 | 39 (41%) | 48 (48%) | |
*
Immune cell infiltrate score, 0: 0 to 5 cells, 1: 5 to 20 cells, 2: greater than 20 cells.
HCC: hepatocellular carcinoma, OR: odds ratio, CI: confidence interval, SH-HCC: steatohepatitic HCC, AFP: alpha-fetoprotein