Table 3.

Tumor-related clinicopathological features associated with HCC molecular subclasses in the training set (logistic regression).

Variable	Univariable analysis			Multivariable analysis
	No. of HCC tumors (%)	OR (95% Cl)	P value	OR (95% Cl)	P value
S1 subclass	S1: n=30 / Rest: n=66
SH-HCC	11 (37%) / 8 (12%)	4.20 (1.47–11.97)	0.007	4.25 (1.44–13.20)	0.01
Immune cell infiltrate ≥ 2	18 (60%) / 21 (32%)	3.21 (1.31–7.87)	0.01	3.25 (1.29–8.53)	0.01
S2 subclass	S2: n=27 / Rest: n=69
Microtrabecular	4 (15%) / 49 (71%)	0.07 (0.02–0.23)	<0.001
Macrotrabecular/compact	22 (81%) / 16 (23%)	14.58 (4.75–44.69)	<0.001	11.99 (3.48–41.24)	<0.001
Pseudoglandular	2 (7%) / 29 (42%)	0.11 (0.02–0.50)	0.004	0.22 (0.04–1.16)	0.07
Clear cell	14 (52%) / 9 (13%)	7.18 (2.56–20.11)	<0.001
Serum AFP > 400 ng/mL	6 (22%) / 2 (3%)	9.57 (1.80–51.03)	0.008	10.81 (1.27–91.63)	0.03
S3 subclass	S3: n=39 / Rest: n=57
Microtrabecular	32 (82%) / 21 (37%)	7.84 (2.94–20.86)	<0.001	3.94 (1.23–12.56)	0.02
Macrotrabecular/compact	6 (15%) / 32 (56%)	0.14 (0.05–0.39)	<0.001
Pseudoglandular	19 (49%) / 11 (19%)	3.56 (1.46–8.71)	0.005
SH-HCC	1 (3%) / 18 (32%)	0.06 (0.01–0.45)	0.006	0.05 (0.01–0.44)	0.007
Clear cell	3 (8%) / 20 (35%)	0.15 (0.04–0.56)	0.005	0.20 (0.05–0.91)	0.04
Edmondson-Steiner I or II	36 (92%) / 42 (74%)	4.29 (1.15–16.00)	0.03	3.08 (0.65–14.58)	0.16

HCC: hepatocellular carcinoma, OR: odds ratio, CI: confidence interval, SH-HCC: steatohepatitic HCC, AFP: alpha-fetoprotein