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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Neurobiol Dis. 2015 Aug 22;83:67–74. doi: 10.1016/j.nbd.2015.08.016

Figure 2. eIF4E/Fmr1 double mutant mice show repetitive behaviors and impairment in social interaction.

Figure 2

(A) Cumulative data of the number of marbles buried in 10-min intervals (**p < 0.01). (B) Time spent interacting with either the stranger mouse or inanimate object in the three-chambered arena test (*p < 0.05) and (C) preference index calculated as time of interaction with the stranger mouse over the total interaction time with either the mouse or the object (*p < 0.05). Data are represented as the mean ± SEM (n = 8-12). WT, 4E Tg, Fmr1 and dMut denote wild-type, eIF4E transgenic, Fmr1 knock-out and eIF4E/Fmr1 double mutant mice, respectively (B, C).