Table 2.
Baseline lipid and lipoprotein measures in relation to incident CVD events among the placebo arm.
| CVD | CVD & all-cause death | ||||
|---|---|---|---|---|---|
| HR per SD higher* (95% CI) | P value | HR per SD higher* (95% CI) | P value | ||
| Lipids and apolipoproteins, mg/dL (SD) | |||||
| LDL cholesterol | 18.5 | 1.03 (0.88-1.21) | 0.71 | 0.92 (0.82-1.03) | 0.16 |
| Non-HDL cholesterol | 23.3 | 1.18 (1.01-1.38) | 0.036 | 1.01 (0.90-1.14) | 0.81 |
| Apolipoprotein B | 21.0 | 1.28 (1.11-1.48) | 0.001‡ | 1.07 (0.96-1.20) | 0.22 |
| Triglycerides | 72.0 | 1.28 (1.11-1.46) | <0.001‡ | 1.17 (1.05-1.30) | 0.005 |
| HDL cholesterol | 15.4 | 0.79 (0.64-0.97) | 0.028 | 0.79 (0.68-0.93) | 0.004‡ |
| Apolipoprotein A-I | 30.5 | 0.79 (0.67-0.94) | 0.009 | 0.77 (0.67-0.89) | <0.001‡ |
| Ion mobility, (SD) | |||||
| Non-HDL particles, nmol/L | 733 | 1.19 (1.05-1.35) | 0.005‡ | 1.06 (0.95-1.17) | 0.32 |
| VLDL particles, nmol/L | |||||
| Total | 59.7 | 1.12 (0.97-1.29) | 0.12 | 0.98 (0.87-1.10) | 0.69 |
| Large | 7.6 | 1.22 (1.05-1.40) | 0.004 | 1.11 (0.99-1.25) | 0.083 |
| Medium | 22.9 | 1.16 (1.01-1.33) | 0.036 | 1.02 (0.91-1.14) | 0.76 |
| Small | 32.0 | 1.05 (0.91-1.22) | 0.52 | 0.92 (0.81-1.03) | 0.15 |
| IDL particles, nmol/L | |||||
| Total | 156 | 1.09 (0.95-1.25) | 0.20 | 0.98 (0.88-1.10) | 0.74 |
| Large | 78 | 1.10 (0.96-1.27) | 0.17 | 0.96 (0.86-1.08) | 0.52 |
| Small | 93 | 1.13 (0.99-1.28) | 0.068‡ | 1.05 (0.94-1.17) | 0.40‡ |
| LDL particles, nmol/L | |||||
| Total | 571 | 1.21 (1.07-1.37) | 0.002‡ | 1.08 (0.97-1.20) | 0.15 |
| I (largest) | 162 | 1.04 (0.90-1.21) | 0.59‡ | 0.95 (0.84-1.07) | 0.42 |
| II a | 115 | 1.11 (0.97-1.28) | 0.14‡ | 0.98 (0.87-1.10) | 0.69 |
| II b | 129 | 1.22 (1.08-1.39) | 0.002‡ | 1.06 (0.95-1.18) | 0.30 |
| III a | 151 | 1.32 (1.13-1.53) | <0.001‡ | 1.15 (1.02-1.30) | 0.018 |
| III b | 78 | 1.17 (1.02-1.35) | 0.027 | 1.09 (0.97-1.21) | 0.15 |
| IV a | 84 | 1.19 (1.04-1.37) | 0.013 | 1.13 (1.01-1.26) | 0.026 |
| IV b | 54 | 1.20 (1.05-1.39) | 0.010 | 1.21 (1.08-1.35) | 0.001‡ |
| IV c (smallest) | 49 | 1.26 (1.10-1.44) | 0.001‡ | 1.36 (1.23-1.52) | <0.001‡ |
| LDL peak diameter, Å | 5.9 | 0.84 (0.73-0.96) | 0.012 | 0.87 (0.78-0.98) | 0.018 |
| HDL particles, μmol/L | |||||
| Total | 17.8 | 1.03 (0.91-1.17) | 0.67 | 0.99 (0.89-1.09) | 0.82 |
| Large | 4.9 | 0.97 (0.85-1.12) | 0.71 | 0.94 (0.84-1.05) | 0.26 |
| Small | 13.4 | 1.05 (0.92-1.18) | 0.48 | 1.01 (0.91-1.11) | 0.91 |
*
Per 1-SD increment in the lipid or lipoprotein variable, adjusted for age, sex, race, smoking, family history, BMI, systolic blood pressure, glucose, and ln hsCRP
Triglycerides, LDL IIIa through IVc, and LDL peak diameter were natural log transformed; values shown are the untransformed SDs.
‡
All measures shown in this table were also evaluated in models that included LDL cholesterol, HDL cholesterol, ln triglycerides in addition to age, sex, race, smoking, family history, BMI, systolic blood pressure, glucose, and ln hsCRP, with variables that met statistical significance (P<0.05) indicated by ‡.