Table 2.
Significant genes that behave differently between nonsmoker and smoker group
| Tests for differences between smokers and nonsmokers |
Difference in expression between tumor and normal for nonsmokers |
Difference in expression between tumor and normal for smokers |
||||
|---|---|---|---|---|---|---|
| GENE | logFC | FDR | logFC | FDR | logFC | FDR |
| Genes exclusively significant in nonsmokers | ||||||
| FGF12 | 1.22 | 3.93E-02 | −1.31 | 7.40E-07 | −0.09 | 7.49E-01 |
| CD207 | −1.94 | 2.47E-02 | 2.04 | 2.97E-07 | 0.10 | 8.28E-01 |
| HOXD1 | −1.76 | 4.23E-02 | 1.43 | 1.67E-04 | −0.34 | 4.36E-01 |
| GDF15 | −1.64 | 2.23E-02 | 2.09 | 1.16E-10 | 0.46 | 1.71E-01 |
| BAAT | −2.05 | 2.38E-02 | 2.81 | 1.41E-11 | 0.76 | 7.38E-02 |
| CLDN2 | −2.50 | 2.34E-02 | 3.18 | 8.96E-10 | 0.68 | 1.74E-01 |
| MUC1 | −1.16 | 4.23E-02 | 1.48 | 8.77E-09 | 0.32 | 2.33E-01 |
| CAPN8 | −1.84 | 6.22E-03 | 2.27 | 8.11E-14 | 0.43 | 2.16E-01 |
| Genes exclusively significant in smokers | ||||||
| FAM83D | 1.47 | 1.30E-02 | 0.53 | 6.33E-02 | 1.99 | 6.46E-14 |
| TYRP1 | −2.09 | 1.52E-05 | −0.09 | 7.85E-01 | −2.17 | 1.02E-15 |
| OLFM1 | −1.41 | 5.41E-03 | −0.35 | 1.55E-01 | −1.76 | 1.66E-13 |
| MYOCD | −1.54 | 2.16E-02 | −0.49 | 1.11E-01 | −2.04 | 9.23E-12 |
| CLEC4F | −1.59 | 7.45E-03 | −0.44 | 1.19E-01 | −2.03 | 8.62E-13 |
| ALPL | −1.85 | 2.23E-02 | −0.18 | 6.71E-01 | −2.02 | 2.53E-08 |
| IGFN1 | −1.91 | 8.40E-03 | 0.19 | 6.26E-01 | −1.72 | 4.20E-07 |
| SCGB3A2 | −2.36 | 3.08E-02 | 0.42 | 4.37E-01 | −1.94 | 8.55E-05 |
| SHH | −2.00 | 7.53E-03 | 0.21 | 5.80E-01 | −1.78 | 6.11E-07 |
| PTCHD1 | −2.11 | 3.12E-03 | −0.53 | 1.35E-01 | −2.64 | 1.82E-14 |
| DPCR1 | −2.31 | 2.26E-02 | 0.41 | 4.15E-01 | −1.90 | 4.01E-05 |
| RAC3 | 1.27 | 1.09E-02 | 0.47 | 5.20E-02 | 1.74 | 1.09E-14 |
| DMBT1 | −2.23 | 4.42E-02 | 0.17 | 7.58E-01 | −2.06 | 7.49E-05 |
| LRRK2 | −1.51 | 3.79E-02 | −0.50 | 1.47E-01 | −2.01 | 7.69E-10 |
| Genes significantly expressed in both groups but with big difference in logFC | ||||||
| ABCC3 | −1.55 | 8.08E-03 | 3.10 | 9.94E-30 | 1.55 | 2.13E-08 |
| KCNK5 | −1.14 | 2.70E-02 | 1.82 | 2.92E-15 | 0.68 | 4.03E-03 |
| CLDN18 | −2.73 | 2.84E-02 | −2.78 | 3.38E-07 | −5.51 | 2.23E-23 |
| PGC | −2.52 | 2.16E-02 | −1.23 | 1.29E-02 | −3.76 | 1.62E-14 |
| SUSD2 | −2.01 | 4.04E-03 | −1.05 | 2.39E-03 | −3.06 | 2.63E-21 |
| GDF10 | −2.04 | 2.57E-03 | −2.40 | 5.35E-14 | −4.44 | 7.96E-39 |
| CNTFR | −2.02 | 2.09E-02 | −2.36 | 1.45E-09 | −4.38 | 4.83E-28 |
| ADAMTS8 | −2.15 | 8.27E-05 | −2.28 | 2.55E-15 | −4.43 | 1.17E-45 |
| RSPO2 | −2.01 | 5.36E-03 | −1.78 | 7.31E-08 | −3.79 | 2.03E-27 |
| GRIA1 | −2.03 | 2.42E-02 | −2.78 | 5.77E-12 | −4.81 | 9.73E-30 |
| MS4A15 | −2.42 | 1.77E-02 | −2.12 | 4.35E-06 | −4.54 | 4.41E-23 |
| SFTPC | −2.77 | 2.69E-02 | −3.89 | 2.57E-11 | −6.66 | 7.14E-27 |
| TMEM132C | −2.64 | 4.87E-03 | −2.24 | 2.17E-07 | −4.88 | 1.50E-27 |