Table 2.

Germ cell mutagenicity classification and standard assays in GHS classification

Category 1. Known/presumed Known to produce heritable mutations in human germ cells
Subcategory 1A Positive evidence from epidemiological studies Subcategory 1B Positive results in: □In vivo heritable germ cell tests in mammals □Human germ cell tests □In vivo somatic mutagenicity tests, combined with some evidence of germ cell mutagenicity
Category 2. Suspected/possible
□May include heritable mutations in human germ cells □Positive evidence from tests in mammals & somatic cell tests □In vivo somatic genotoxicity supported by in vitro mutagenicity

GHS, Globally Harmonized System of Classification and Labeling of Chemicals.

Note. From: A Guide to The Globally Harmonized System of Classification and Labeling of Chemicals (GHS) [Internet]. Washington (DC):Occupational Safety and Health Administration (OSHA). 2003 [cited 2015 Jun 18]. Available from: https://www.osha.gov/dsg/hazcom/ghs.html#3.2. Copyright 2013, Occupational Safety and Health Administration (OSHA), Reprinted by permission.