Table 7.
The sensitivity, specificity, and predictivity of the assays of the standard regulatory test battery for the assessment of carcinogenicity [18], [19]
| Assay | Sensitivity (%) | Specificity (%) | Predictivity (%) |
|---|---|---|---|
| Ames test | 58.8 | 73.9 | 62.5 |
| Chromosome aberration test | 65.6 | 44.9 | 59.8 |
| Mouse lymphoma TK test | 73.1 | 39.0 | 62.9 |
| Micronucleus test in vitro | 78.7 | 30.8 | 67.8 |
| Micronucleus test in vivo | 40.0 | 75.0 | 48.0 |
TK, thymidine kinase.
Note. From P. Steinberg (editor), High-throughput Screening Methods in Toxicity Testing, p. 213–69, Copyright 2013, Hoboken (NJ): John Wiley & Sons, Inc., Adapted with permission.