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. 2015 Dec 10;9:335. doi: 10.3389/fnbeh.2015.00335

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Copyright © 2015 de Sá-Calçada, Roque, Branco, Monteiro, Cerqueira-Rodrigues, Sousa, Palha and Correia-Neves.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The three mouse strains present differences in locomotor and exploratory activities, as well as in anxious and depressive-like behaviors. OFT, FST, and TST were performed in CD-1 (gray bars), C57BL/6 (black bars), and Balb/c (white bars) mice. In the OFT the total distance traveled (A), the number and duration of rearings (B), and the percentage of distance traveled in the center of the OFT's arena (C) were scored, and used as a measure of locomotion, exploratory activity, and anxious-like behavior, respectively. In the FST (D) and TST (E), the latency to immobility and immobility times were scored and used as measures of depressive-like behavior. Each bar represents the mean + SEM from 11 to 21 mice of 1 of 2 independent experiments with similar results. ^*p < 0.05; ^**p < 0.01; ^***p < 0.001; ^****p < 0.0001.