Table 1.
Metabolite | Genes and gene cluster | Size (bp) | Genome position (bp) | MIBiG | Effect against | Reference |
---|---|---|---|---|---|---|
Sfp-dependent non-ribosomal synthesis of lipopeptides (NRP) | ||||||
Surfactin | srfABCD | 28,544 | 341,664-370,208 | BGC0000433 | virus, Mycoplasma | Koumoutsi et al., 2004 |
Bacillomycin D | bmyCBAD | 39,113 | c1,908,427-c1,869,309 | BGC0001090 | fungi | Koumoutsi et al., 2004 |
Fengycin | fenABCDE | 37,669 | c1,968,997-c1,931,328 | BGC0001095 | fungi | Koumoutsi et al., 2004 |
Bacillibactin | dhbABCDEF | 11,954 | c3,032,970-c3,021,016 | BGC0001185 | microbial competitors | Chen et al., 2007 |
Sfp-dependent non-ribosomal synthesis of polyketides (PKS) | ||||||
Macrolactin | mlnABCDEFGHI | 53,253 | 1,391,841-1,445,094 | BGC0000181 | bacteria | Schneider et al., 2007 |
Bacillaene | baeBCDE, acpK, baeGHIJLMNRS | 72,437 | 1,700,345-c1,772,782 | BGC0001089 | bacteria | Chen et al., 2006 |
Difficidin | dfnAYXBCDEFGHIJKLM | 69,523 | c2,276,743-c2,346,266 | BGC0000176 | bacteria | Chen et al., 2006 |
Sfp-independent non-ribosomal synthesis (NRP) | ||||||
Bacilysin | bacABCDE, ywfG | 5,907 | c3,593,877-c3,599,784 | BGC0001184 | bacteria | Chen et al., 2009b |
Ribosomal synthesis of processed and modified peptides (bacteriocins, lantibiotics, RiPPs) | ||||||
Plantazolicin | pznFKGHIAJC DBEL | 9,891 | 726,457-736,348 | BGC0000569 | B. anthrax, nematodes | Scholz et al., 2011 |
Amylocyclicin | acnBACDEF | 4,112 | c3,048,678-c3,044,568 | BGC0000616 | related bacteria | Scholz et al., 2014 |
Mersacidin (partial) | mrsK2R2FGE | 4,828 | c3,774,552-c3,769,734 | BGC0000527 | Gram-+ bacteria | Borriss, 2013 |
The available MIBiG entries (Medema et al., 2015) are indicated.