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. 2015 Dec 10;9:471. doi: 10.3389/fncel.2015.00471

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Copyright © 2015 Dagostin, Lovell, Hilscher, Mello and Leão .

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) A computer model shows that a potassium leak conductance is sufficient to switch firing from tonic to phasic. (A) Firing of a model phasic NCM neurons with a range of potassium leak conductances (gL), from 7.6 to 2 nS. The darker traces show examples of phasic, transient and tonic firing. (B) Graph showing the number of APs fired by the model vs. the leak conductance. The light traces represent different IKdr levels of conductance (from 60 to 140% of the average IKdr conductance of a phasic neuron), and the open symbols the average. The shaded area represents the transient firing expression, being phasic firing expressed below and tonic firing above it. (C) Comparison of the background conductances of the different neuronal types obtained from the data in Figure 3B with the data from the model. The box and whisker plot represents the 25–75% percentiles of the experimental data, and the bars the minimum and maximum points. The shaded area shows the levels of background conductance producing transient firing and the arrows the conductance levels producing phasic (above) and tonic (below) firing in the model. (D) Plot showing of the number of APs fired vs. leak conductance in a model with the average VAKC from a phasic neuron (IKdr) and adding an A-type potassium current (IKa), a 20 nS low-threshold potassium current (Klt 20), 200 nS of IKlt (IKlt200) and a high-threshold potassium current (IKht).