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. 2015 Dec 10;9:471. doi: 10.3389/fncel.2015.00471

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Copyright © 2015 Dagostin, Lovell, Hilscher, Mello and Leão .

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of potassium leak conductances by Ba²⁺ 5 mM changes phasic firing to tonic firing. (A) Example of the firing of a phasic neuron before and after the application of BaCl₂ 5 mM. Negative DC current was injected in the presence of Ba²⁺ to repolarize the RMP. (B) Current–voltage (IV) relationships of the voltage-activated potassium currents in phasic neurons before and after successive application of TEA (5 mM)/four-AP (5 mM) and BaCl₂ (5 mM). n = 7. (C) Data from (B) normalized to the peak of current at 70 mV.