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Change in proteasome activity following MPP+ and PF treatment. Under normal circumstances, the impact of PF on proteasome activity was not statistically significant (P = 0.076). MPP+ inhibited the ubiquitin-proteasome activity (P = 0.002). Paeoniflorin reversed the decline of proteasome activity caused by MPP+ (P = 0.004) (## P < 0.01 MPP+ group versus control group; ∗∗ P < 0.01 versus MPP+ group; mean ± SD, n ≥ 6).
