. 2015 Feb 21;16(5):1108–1121. doi: 10.1208/s12249-015-0294-0

Table IV.

Pharmacokinetics of ^99mTc-DNP (i.n), ^99mTc-DS (i.n), and ^99mTc-DS (i.v) at Different Time Intervals Sprague Dawley Rats

	Organ/tissue	C _max (%/g)	T _max (h)	AUC_0→480
^99mTc-DS (i.v)	Blood	3.09	0.5	15.10
^99mTc-DS (i.v)	Brain	1.73	2	7.95
^99mTc-DS (i.n)	Blood	1.83	1	11.02
^99mTc-DS (i.n)	Brain	1.81	0.5	7.30
^99mTc-DNP (i.n)	Blood	2.35	2	13.92
^99mTc-DNP (i.n)	Brain	3.07	1	18.94

The rats were administered 100 μCi ^99mTc-Dzp, and the radioactivity was measured in percent per gram of tissue of the administered dose. Each value is the mean ± SD of three estimations. Only statistically significant outcomes at p < 0.05 have been reported

AUC area under the curve, DS Dzp suspension, DNP Dzp nanoparticles, i.v intravenous, i.n intranasal