Table II.

Composition of Medicated Chewing Gum

Formulation code	Calcium carbonate (mg) (X 1)	Gum base (mg) (X 2)	Drug (mg)	PVA (mg)	Sodium saccharin (mg)	Glycerin (mL)	Peppermint oil (mL)
F1	−1	−1	5	50	10	0.05	0.01
F2	0	−1	5	50	10	0.05	0.01
F3	1	−1	5	50	10	0.05	0.01
F4	−1	0	5	50	10	0.05	0.01
F5	0	0	5	50	10	0.05	0.01
F6	1	0	5	50	10	0.05	0.01
F7	−1	1	5	50	10	0.05	0.01
F8	0	1	5	50	10	0.05	0.01
F9	1	1	5	50	10	0.05	0.01

X1 amount of calcium carbonate [70 mg (−1), 80 mg (0), 90 mg (1)], X2 Amount of gum base [450 mg (−1), 500 mg (0), 550 mg (1)], PVA polyvinyl acetate