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a The percentage of cell viability among 
HaCaT cells and 
HGFs in the presence of α-mangostin at 0–1 μg/ml for 24 h and the percentage of cell viability among HaCaT cells and HGFs following (b and c) acute or (d and e) long-term exposure to the mucoadhesive nanofiber mats containing different amounts of α-mangostin, serving as an indicator of cytotoxicity: incubation for 
15, 
30, 
60, 
120, 
240 min, 
24, 
48, and 
72 h. *p <0.05
