Table I.
Formulation Compositions, Particle Size, Polydispersity Index (PI), Zeta Potential, Mole Ratio, Positive/Negative (+/−) Charge Ratio, and Drug Entrapment Efficiency (EE) of DC-TMCNs (n = 3, Mean ± SD)
| Formulation | Content of ingredients (g) | Weight ratio of TMC/DC/TPP | Particle size (nm) | PI | Zeta potential (mV) | Mole ratio of TMC/(DC + TPP) | +/− charge ratio | EE (%) | ||
|---|---|---|---|---|---|---|---|---|---|---|
| TMC | DC | TPP | ||||||||
| 2TMC-1DC-1TPP | 0.12 | 0.06 | 0.06 | 2:1:1 | 131 ± 2 | 0.3 ± 0.1 | 6.3 ± 1.0 | 1.47 | 0.26 | 74.6 ± 0.2 |
| 3TMC-1DC-1TPP | 0.18 | 0.06 | 0.06 | 3:1:1 | 155 ± 1 | 0.2 ± 0.0 | 8.3 ± 0.5 | 2.21 | 0.39 | 93.3 ± 0.1 |
| 3TMC-1DC-2TPP | 0.18 | 0.06 | 0.12 | 3:1:2 | 162 ± 2 | 0.3 ± 0.0 | 4.7 ± 0.1 | 1.51 | 0.21 | 96.2 ± 0.2 |
| 3TMC-1DC-3TPP | 0.18 | 0.06 | 0.18 | 3:1:3 | 169 ± 2 | 0.4 ± 0.0 | 4.3 ± 0.3 | 1.15 | 0.15 | n.d. |
| 4TMC-1DC-1TPP | 0.24 | 0.06 | 0.06 | 4:1:1 | 188 ± 2 | 0.3 ± 0.0 | 8.9 ± 0.5 | 2.94 | 0.52 | 88.3 ± 0.2 |
n.d. not determined