Table I.

In vitro Transcorneal Permeability Coefficients of PHCl at Different Concentrations of CDs. (I) IPBS without CDs (Control; 1), (II) CDs in the Donor Solution (3 and 6), (III) CDs in the Receiver Solution (2 and 5), and (IV) CDs in Both the Donor and Receiver Solutions (4 and 7). Experiments were Carried out for 1 or 3 h

S. No	Donor	Receiver	Permeability × 106 cm/s
	3 ml	3.2 ml	5% w/v CDs	2.5% w/v CDs
1	IPBS	IPBS	27.0 ± 1.3	21.3 ± 1.0
2	IPBS	HPβCD	40.8 ± 5.7	32.2 ± 4.5
3	HPβCD	IPBS	8.1 ± 1.2	6.4 ± 1.0
4*	HPβCD	HPβCD	17.6 ± 1.1	13.8 ± 0.9
5	IPBS	RMβCD	52.1 ± 8.4	41.3 ± 6.6
6	RMβCD	IPBS	14.5 ± 5.2	11.4 ± 4.1
7a	RMβCD	RMβCD	24.5 ± 3.4	19.2 ± 2.7

CDs cyclodextrins, IPBS isotonic phosphate-buffered solution, HPβCD 2-hydroxypropyl-beta-cyclodextrin, RMβCD randomly methylated-beta-cyclodextrin

^aExperiments were carried out for 1 and 3 h. Permeability coefficients were calculated only for a 1-h experiment.