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. 2015 Dec 10;5:17637. doi: 10.1038/srep17637

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Copyright © 2015, Macmillan Publishers Limited

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(a) A representative patch-clamp recording showing the activation of TRPC channels in the podocytes of the control (vehicle-treated) SS rats in response to application of 1 μM Ang II, followed by a washout of Ang II. c and o_i denote closed and open states of the channel, respectively; a full recording (upper row) and a fragment of a recording at a larger scale are shown. The recording was obtained at −60 mV. (b) Right panel demonstrates a summary graph of the open probability (P_o) of the TRPC channels recorded in the podocytes of the STZ-treated animals compared to control rats after acute stimulation with 1 μM of Ang II. Representative current traces illustrating TRPC channels’ activity in podocytes of diabetic rats vs. control animals (before and after application of Ang II) are shown on the left panel. N represents number of animals studied, and n is the number of analyzed patch-clamp recordings; the recordings were obtained at −60 mV. * and ^# denote statistical significance (P < 0.05).