Table 7.
TNF-α genotypes and survival in Okuda stage III hepatocellular carcinoma cases
| Genotype |
Validation set |
Adjusted HR (95%CI)1 | P-value | |
| Cases (n = 43) | Deaths (n = 41) | |||
| TNF-α -1031 T>C, rs1799964 | ||||
| TT | 29 (67.4) | 27 (65.9) | 1.000 (reference) | |
| TC | 11 (25.6) | 11 (26.8) | 1.314 (0.448-3.856) | 0.621 |
| CC | 3 (7.0) | 3 (7.3) | 5.795 (1.145-29.323) | 0.035 |
| Dorminant model (TT vs TC + CC) | 1.805 (0.733-4.442) | 0.201 | ||
| Recessive model (TT + TC vs CC) | 3.761 (0.869-16.265) | 0.078 | ||
1
Adjusted for age, sex, hypertension, diabetes mellitus, drinking status, smoking status, portal vein thrombosis, tumor size, surgical resection, and chemotherapy or radiotherapy.