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. 2015 Nov 26;6:8966. doi: 10.1038/ncomms9966

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(a–c) DNA damage response markers H2AX-pS139 (a), p53 (b) and p53-pS15 (c) are increased in astrocytes of GFAP^R236H/+ and GFAP^Tg mice (arrows), but not in age-matched wild-type littermate controls (arrowheads). GFAP marks astrocytes. 4,6-Diamidino-2-phenylindole (DAPI) labels nuclei. (d) p53 and p53-pS15 colocalize with H2AX-pS139 in GFAP^Tg mice (arrows). DAPI labels nuclei. (e) H2AX-pS139, p53 and p53-pS15 colocalize with CNGA4 in GFAP^Tg mice (arrows). DAPI labels nuclei. Mice were 3 months old in all panels. Scale bar, 20 μm.