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. 2015 Nov 26;6:8966. doi: 10.1038/ncomms9966

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(a) Quantification of iNOS protein levels reveals an increase in Alexander disease patients. *P=0.0042, t=2.326, df=8; unpaired t-test, n=5 for both ctrl and AxD. (b) Double-label immunofluorescence shows activation of p53 in astrocytes of Alexander disease patient (arrows), but not in control (arrowheads). Images were taken from the grey matter in frontal cortex. GFAP labels astrocytes. 4,6-Diamidino-2-phenylindole (DAPI) marks nuclei. Scale bar, 10 μm.