Table 1.

Representative mouse models of AD

Mouse model	Gene/ isoform	Mutation	Intraneuronal Aβ	Parenchymal Aβ plaques	Tau hyperphos -phorylation	Neurofibrillary tangles	Neuronal loss	Key references
hAPP models
PDAPP	hAPP695< 751,770a	Ind	-	Yes	Yes	No	No	[24, 25]
APP23	hAPP751	Swe	-	Yes	Yes	No	Little	[26]
Tg2576	hAPP695	Swe	Yes	Yes	-	-	No	[27]
J20	hAPP695< 751,770a	Swe, Ind	-	Yes	No	No	Yes	[31]
TgCRND8	hAPP695	Swe, Ind	-	Yes	-	No	No	[72]
hAPP/PS1 models
APP/PS1 (Tg2576 × PS1)	hAPP695	Swe	-	Yes	-	-	-	[33]
	PSEN1	M146L
APPswePS1ΔE9	m/hAPP695b	Swe	-	Yes	No	No	-	[34]
	PSEN1	ΔE9
APPSL/PS1	hAPP751	Swe, Lon	Yes	Yes	-	-	Yes	[73]
	PSEN1	M146L
APP/PS1KI	hAPP751	Swe, Lon	Yes	Yes	-	-	Yes	[36]
	PSEN1	M233T, L235P
5xFAD	hAPP695	Swe, Lon, Flo	Yes	Yes	-	-	Yes	[37]
	PSEN1	M146L, L286V
Models with hTau
TAPP	hAPP695	Swe	-	Yes	-	Yes	-	[39]
	hTau-4R0 N	P301L
3xTg	hAPP695	Swe	Yes	Yes	Yes	Yes	No	[40]
	hTau-4R0 N	P301L
	PSEN1	M146V
Other models
APPSwDI/NOS2−/−	hAPP770	Swe, Dutch, Iowa	No	Yes	Yes	Yes	Yes	[41]
	NOS2	Knockout
TgF344-AD rats	m/hAPP695b	Swe	Yes	Yes	Yes	Yes	Yes	[42]
	PSEN1	ΔE9

^aAPP minigene expressing all three isoforms, mostly KPI-positive APPs.

^bHumanized mouse APP, in which three amino acids in Aβ are changed to the human sequence.

Ind, Indiana; Swe, Swedish; Lon, London

Dash (−) = not reported.