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. 2015 Dec 10;5:17440. doi: 10.1038/srep17440

Figure 6. Use of shock wave adjunct therapy in the treatment of murine suture associated S. aureus infections.

Figure 6

BALB/c mice were provided abdominal sutures after 3 days the sutures were removed. SEM of untreated sutures revealed that sterile sutures did not develop obvious biofilms (a). (b) SEM of Sterile suture treated with shock wave. Mice were also given sutures where the surgical wire was pre-incubated with S. aureus (c-f). After 3 days the mice were killed and the sutures examined by SEM. The excised S. aureus biofilm-coated sutures were left untreated (c), treated ex vivo with ciprofloxacin alone (4 μg/ml for 6 h) (d), shock wave therapy alone (e) or a combination of ciprofloxacin and shock wave (f). Scale bar in e–10 μm. (g) The bacteria were enumerated in the suture with or without any treatment by homogenizing by ultrasonication and plating. Statistical significance was calculated using One-way ANOVA. Asterisks indicate statistical significance as follows: (**p < 0.005), ( p < 0.001). Error bar–mean ± SD.