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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Mol Aspects Med. 2015 Nov 5;46:21–33. doi: 10.1016/j.mam.2015.09.003

Figure 2. Transcriptional regulation of hepatic glucose output (HGP).

Figure 2

The transcriptional programs controlling the expression of gluconeogenic genes in hepatocytes are regulated by insulin and glucagon. Insulin, by activating Akt, leads to phosphorylation and nuclear exclusion of FoxO1 and subsequent suppression of gluconeogenic genes. Glucagon, by increasing intracellular cAMP levels, activates PKA and results in activation of CREB and subsequent activation of gluconeogenic genes.