Table 3.

Examples of pathway event errors.

PMID	Sentence	PWTEES	Comment
8875985	...directed the expression of either the A2a adenosine receptor that constitutively activates the cAMP pathway, or the E7 protein	T: cAMP cascade C: E7 protein ET: Positive regulation	The cause should be A2a adenosine receptor. Wrong assignment of argument.
23261982	Dkk-1 inhibited the survival and migration of human PTC cells by regulating Wnt/β-catenin signaling and E-cadherin expression.	T: expression of Wnt/beta-catenin signaling and E-cadherin C: Wnt/beta-catenin signaling pathway ET: Regulation	Cause should be Dkk-1 and event type is inhibition. Wrong assignment of argument and event type.
21690267	...the same patient allele carries both K666E and G691S variants, the latter known to increase downstream RET signaling,	T: RET downstream signaling C: ET: Positive regulation	Cause should be G691S variants. Missed argument
15059947	...the MAPK (ERK1/2) signaling pathway causes serine phosphorylation by MAPK of several nucleoproteins	T:{T:MAPK; Site: serine; ET: Phosphorylation} C: MAPK (ERK1/2) signaling pathway ET: Positive Regulation	In the nested theme event, MAPK should be the cause, not the theme.
16940797	ZD 6474 has shown promising activity in preclinical models against RET kinase, and its contemporary inhibition of vascular endothelial growth factor and epidermal growth factor pathways	T: VEGF and EGF pathways C: ET: Negative Regulation	Cause should be ZD6474 (drug).

T - Theme, C - Cause, ET - Event Type