Table 4.

EVEX and PWTEES differences on example sentences.

Example sentence	PMID	EVEX	PWTEES
Mutated BRAF, generates a constitutive activation of the mitogen-activated protein kinases (MAPK) signaling pathway	22863493	N/A	T: Activation of MAPK pathway C: BRAF ET: Positive regulation
PLD synergistically functions to activate the STAT3 signaling by interacting directly with the thyroid oncogenic kinase RET/PTC.	18498667	T1: PLD T2: RET/PTC ET: Binding	T: PLD C: STAT3 signaling ET: Positive regulation
CD40 stimulation inhibits cell growth and Fas-mediated apoptosis in a thyroid cancer cell line.	10223618	Gene/Protein: CD40, Fas	T: Fas-medicated apoptosis C: CD40 stimulation ET: Negative regulation
.. and that integration of the Ras/ERK1/2/ELK-1 and STAT3 pathways was required for up-regulation of the c-fos promoter by FMTC-RET	17209045	T: c-fos promoter C: FMTC-RET ET: Positive regulation	T: up-regulation of the c-fos promoter by FMTC-RET C: Ras/ERK1/2/ELK-1 and STAT3 pathways ET: Positive regulation

T - Theme, C - Cause, ET - Event Type