Table 3.

Resistance to therapy for chronic Hepatitis B treatment [11–16]

Years	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
Resistance
TDF	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
ETV	0.2	0.3	0.7	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
3TC	6.7	11.3	21.0	11.3	6.4	3.2	1.6	0.8	0.4	0.2	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
LtD/Hbe−	1.1	2.2	4.1	2.2	1.2	0.6	0.3	0.2	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
LtD/Hbe+	5.0	6.3	11.6	6.3	3.5	1.8	0.9	0.4	0.2	0.1	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Cumulative resistance
TDF	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
ETV	0.2	0.5	1.2	1.2	1.2	1.2	1.2	1.2	1.2	1.2	1.2	1.2	1.2	1.2	1.2	1.2	1.2	1.2	1.2
3TC	6.7	18.0	39.0	50.3	56.7	59.9	61.5	62.3	62.7	62.9	63.0	63.1	63.1	63.1	63.1	63.1	63.1	63.1	63.1
LtD/Hbe−	1.1	3.3	7.4	9.6	10.8	11.4	11.8	11.9	12.0	12.0	12.1	12.1	12.1	12.1	12.1	12.1	12.1	12.1	12.1
LtD/Hbe +	5.0	11.3	22.9	29.1	32.7	34.4	35.3	35.8	36.0	36.1	36.1	36.2	36.2	36.2	36.2	36.2	36.2	36.2	36.2

Values are expressed as %