Fig. 3.

Histograms correlating gene expression with methylation. Allelic gene expression for each extended bait probe was normalized across the sub-genomes so that per site cumulative expression values for the individual A, B and D sub-genomes were all equal to 100 %. The x-axis is divided into 20 individual 5 % interval bins that correspond to allelic gene expression. The y-axis is the percentage of total counts for each respective bin, i.e., the frequency of methylated cytosine sites per sub-genome plotted against allelic gene expression for the extended bait sequence from which the site originated. This is shown for tri-methylated residues (a, d, g) bi-methylated residues (b, e, h) and uni-methylated residues (c, f, i) and data are further categorized as in non-transcribed regions associated closely with a gene (a, b, c), promoter regions (d, e, f) and transcribed regions (g, h, i)