Fig. 3.

Hyperphosphorylated tau accumulation in the entorhinal cortex and locus ceruleus of cat brains. a Immunohistochemistry of the entorhinal cortex of a cat with mild hyperphosphorylated tau accumulation (15-year-old, case No. 13) for hyperphosphorylated-tau (AT8). The neuronal soma and dendrites are positively stained for hyperphosphorylated tau. Bar = 20 μm. b Immunohistochemistry of the entorhinal cortex and locus ceruleus of a cat with severe hyperphosphorylated tau accumulation (14-year-old, case No. 12) for AT8, 3-repeat tau (RD3), and 4-repeat tau (RD4). AT8-positive aggregates are also positively stained for 3-repeat tau and 4-repeat tau on consecutive sections. Bar = 300 μm