Table 2.
Species | Life span | Aβ | Tau | Neuron loss | ||||
---|---|---|---|---|---|---|---|---|
Sequence vs. human | Oligomers | SP | Sequence vs. human | Isoformsa | NFT | |||
Human | 80 yrs | — | Yes | Yes | — | 3R + 4R (6) | Yes | Yes |
Chimpanzee | 60 yrs | 100 % | ND | Yes | 100 % | 3R + 4R (6) | No | No |
Dog | 20 yrs | 100 % | Yes | Yes | 92 % | 3R + 4R (4) | No | No |
Cat | 20 yrs | 1 a.a. different | Yes | No | 93 % | 3R + 4R (6) | Yes | Yes |
Mouse | 2 yrs | 3 a.a. different | No | No | 89 % | 4R (3) | No | No |
aparenthesis indicate the number of total tau isoforms; yrs, years; a.a., amino acid(s); ND, no data