Table 3.

Between-day variability in pharmacokinetic and pharmacodynamic variables

	Within-subject CV% (90% CI)	Between-subject CV% (90% CI)
INS-AUC0–24*	17.4 (15–21)	34.8 (29–43)
	15.3 (13–19)†	34.1 (28–43)†
INS-Cmax*	33.4 (28–41)	25.6 (16–35)
	19.4 (17–24)†	23.0 (18–30)†
GIR-AUC0–24‡	34.8 (30–42)	43.2 (34–55)
GIRmax‡	27.9 (24–34)	23.9 (16–32)

AUC, area under the curve; CI, confidence interval; CV%, coefficient of variation; INS, serum insulin concentration; GIR, body weight standardized glucose infusion rate.

^*CV% is of geometric type.

^†Excluding outliers. Three participants excluded from this analysis owing to presenting INS-C_max outlier values (>31.4 µU/ml), one participant on the reference treatment and two on the test treatment.

^‡CV% is based on untransformed data.