Table 3.
Semi-quantitative scoring of neuropathological markers
| LBC | AD | LBC | AD | ||||
|---|---|---|---|---|---|---|---|
| Region | Stain | Score | Region | Stain | Score | ||
| BA9 | TDP43 | - | ++ | BA41/42 | TDP43 | - | + |
| pTAU | - | +++ | pTAU | - | +++ | ||
| BA4 | + | +++ | BA4 | + | +++ | ||
| a-Syn | - | - | a-Syn | - | - | ||
| GFAP | + | +++ | GFAP | ++ | +++ | ||
| CD68 | + | +++ | CD68 | + | + | ||
| UBIQ | + | +++ | UBIQ | + | +++ | ||
| BA44/45 | TDP43 | + | + | EC | TDP43 | + | ++ |
| pTAU | - | +++ | pTAU | + | +++ | ||
| BA4 | - | +++ | BA4 | ++ | +++ | ||
| a-Syn | - | - | a-Syn | - | - | ||
| GFAP | + | ++ | GFAP | + | +++ | ||
| CD68 | ++ | ++ | CD68 | + | ++ | ||
| UBIQ | + | +++ | UBIQ | ++ | +++ | ||
| BA46 | TDP43 | + | ++ | BA17 | TDP43 | + | ++ |
| pTAU | - | +++ | pTAU | - | +++ | ||
| BA4 | - | +++ | BA4 | + | +++ | ||
| a-Syn | - | - | a-Syn | - | - | ||
| GFAP | + | ++ | GFAP | + | +++ | ||
| CD68 | + | ++ | CD68 | + | + | ||
| UBIQ | + | +++ | UBIQ | + | +++ | ||
| BA6/8 | TDP43 | + | ++ | BA24 | TDP43 | + | ++ |
| pTAU | - | +++ | pTAU | - | +++ | ||
| BA4 | + | +++ | BA4 | - | +++ | ||
| a-Syn | - | - | a-Syn | - | - | ||
| GFAP | + | +++ | GFAP | + | ++ | ||
| CD68 | + | +++ | CD68 | + | ++ | ||
| UBIQ | + | +++ | UBIQ | + | +++ | ||
BA9 = Prefrontal cortex, BA44/45 = Broca’s area, BA46 = Dorsolateral Prefrontal cortex, BA6/8 = Premotor cortex, BA41/42 = Superior Temporal cortex, EC = Entorhinal cortex, BA17 = Primary Visual cortex, BA24 = Anterior Cingulate cortex. “-” = no pathology, “+” = mild pathology, “++” = moderate pathology, “+++” = strong pathology. Example images for each score are found in Supplementary Figure 2.