Table 1.
Outcomes reported in literature for standard epi-off CXL procedures (2010–2015)
| Author (Year) | Follow-up | Results | Type of Study | Number of Eyes | Indication | |||
|---|---|---|---|---|---|---|---|---|
| Kmax | K1/K2 | Mean Keratometry | BCVA | |||||
| Lang S et al. (2015) [23] | 3 years | D | - | RCS | 29 | Keratoconus | ||
| Poli M et al. (2015) [24] | 6 years | S | I | PCS | 36 | Ectasia | ||
| Di Bernardo M et al. (2015) [25] | 2 years | D | I | PCS | 57 | Keratoconus | ||
| McAnena L et al. (2015) [26] | 3 years | S | I | RCS | 25 | Pediatric Keratoconus | ||
| Sedaghat M et al. (2015) [27] | 1 year | S | D | I | PCS | 97 | Keratoconus | |
| Khan WA (2015) [28] | 3 years | D | I | PCS | 71 | Keratoconus | ||
| Yildirim A et al. (2014) [29] | 42 months | D | I | RCS | 20 | Post LASIK ectasia | ||
| Kymionis GD et al. (2014) [30] | 5 years | D | I | PCS | 25 | Keratoconus | ||
| Kumar Kodavoor S (2014) [31] | 1 year | S | I | RCS | 24 | Pediatric Keratoconus | ||
| Viswanathan D et al. (2014) [32] | 20 months | D | S | PCS | 25 | Pediatric Keratoconus | ||
| Goldich I et al. (2014) [33] | 3 years | S | S | PCS | 17 | Keratoconus | ||
| Steinberg J et al. (2014) [34] | 2 years | D | I | PCS | 20 | Keratoconus | ||
| Wittig-Silva C et al. (2014) [35] | 3 years | D | I | RCT | 100 | Keratoconus | ||
| Elbaz U et al. (2014) [36] | 1 year | S | S | PCS | 9 | Radial Keratotomy | ||
| Ghanem RC et al. (2014) [37] | 2 years | D | I | PCS | 42 | Keratoconus | ||
| Toprak I et al. (2013) [38] | 1 year | D | I | RCS | 59 | Keratoconus | ||
| Hashemi H et al. (2013) [39] | 5 years | D | I | PCS | 40 | Keratoconus | ||
| Richoz O et al. (2013) [40] | 2 years | D | I | RCS | 26 | Post LASIK/PRK ectasia | ||
| Ivarsen A et al. (2013) [41] | 22 months | D | S | RCS | 22 | Keratoconus | ||
| Legare ME et al. (2013) [42] | 2 years | S | S | RCS | 39 | Keratoconus | ||
| O’Brart (2013) [43] | 4-6 years | S | S | RCS | 30 | Keratoconus | ||
| Arora R et al. (2012) [44] | 12 months | I | PCS | 15 | Pediatric Keratoconus | |||
| Chatzis N et al. (2012) [45] | 3 years | S | I | RCS | 59 | Pediatric Keratoconus | ||
| Vinciguerra R et al. (2013) [46] | 4 years | D | I | RCS | 400 | Keratoconus | ||
| Viswanathan D et al. (2013) [47] | 14 months | D | I | PIS | 76 | Keratoconus | ||
| Poli M. et al. (2013) [48] | 3 years | S | S | PC | 55 | primary and secondary ectasia | ||
| Lamy R et al. (2013) [49] | 2 years | D | I | PC | 68 | Keratoconus | ||
| Kranitz K et al. (2012) [50] | 1 year | D | I | PC | 40 | Keratoconus | ||
| Guber I et al. (2013) [51] | 1 year | S | I | PCS | 33 | Keratoconus | ||
| Vinciguerra P et al. (2012) [52] | 2 years | K1 S/ K2 D | I | PCS | 40 | Pediatric Keratoconus | ||
| Caporossi A et al. (2012) [53] | 3 years | D | I | PCS | 152 | Pediatric Keratoconus | ||
| Goldich I et al. (2012) [54] | 2 years | D | I | PCS | 14 | Keratoconus | ||
| Asri D et al. (2011) [55] | 1 year | S | S | PCS | 142 | Keratoconus | ||
| Fuentes-Paez G et al. (2012) [56] | 6 months | S | I | PCS | 7 | Ectassia post RK | ||
| Kymionis GD et al. (2012) [57] | 1 year | S | S | PCS | 14 | Keratoconus | ||
| Koller T et al. (2011) [58] | 1 year | D | S | PCS | 151 | Keratoconus | ||
| Greenstain SA et al. (2011) [59] | 1 year | D | S | RCT | 71 | Primary and secondary ectasia | ||
| Raiskup F et al. (2011) [60] | 1 year | S | S | RCS | 32 | Keratoconus | ||
| Hersh P et al. (2011) [61] | 1 year | S | I | RCT | 71 | Keratoconus | ||
| Salgado JP et al. (2011) [62] | 1 year | S | S | PCS | 22 | Post LASIK ectasia | ||
| Caporossi A et al. (2010) [63] | 4 years | D | I | PCS | 44 | Keratoconus | ||
| Vinciguerra P et al. (2009) [64] | 2 years | D | I | PCS | 28 | Keratoconus | ||
| Vinciguerra P et al. (2010) [65] | 1 year | D | I | PCS | 13 | Post LASIK/PRK ectasia | ||
S= Stabilized, D= Significantly decreased, I= Significantly improved, PCS= Prospective case series, RCS= Retrospective case series, RCT= Randomized controlled trial, PIS= Prospective interventional study, PC= Prospective comparative