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Concentration–response curves to noradrenaline (a), L-NAME (b), acetylcholine (c) and sodium nitroprusside (d) in aortic rings isolated from Lcatwt and LcatKO mice. For panels b, c and d, tissues were precontracted with noradrenaline (10− 7 M), and then incubated with increasing concentrations of L-NAME, acetylcholine or sodium nitroprusside (n = 6). #P < 0.005 and *P < 0.05 vs Lcatwt. L-NAME = NG-nitro-l-arginine methyl ester.
