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. 2015 Dec 7;6:10099. doi: 10.1038/ncomms10099

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(a) DARPP-32 can interact with β-adducin MARCKS domain and this interaction is increased by phosphorylation of DARPP-32 on Ser97 by CK2. When DARPP-32 is phosphorylated by CDK5 on Thr75 it inhibits PKA (red line with round end). Since PKA activates PP2A, which dephosphorylates β-adducin Ser713, pThr75-DARPP-32 increases β-adducin phosphorylation level (resulting from PKC action). (b) Phosphorylation of β-adducin prevents its interaction with actin and spectrin and destabilizes cortical cytoskeleton in dendrites and spines. This destabilization facilitates spine plasticity in response to NEE. Schematic representation of adducin tetramer and actin/spectrin is modified from ref. 19.