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. 2015 Dec 7;6:10099. doi: 10.1038/ncomms10099

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WT (a) and β-adducin KO littermates (b) were housed for 24 h in their home cage or under NEE conditions, as indicated. After a 30-min habituation in the circular maze, all mice were injected with cocaine (arrow, 20 mg kg⁻¹, intraperitoneal). Locomotor activity was recorded in 5-min bins. WT (a): 15 (home cage) and 17 (NEE) mice per group in 3 experiments; two-way ANOVA: housing factor, F_(1,540)=16.54, P<10⁻⁴; time factor, F_(17,540)=18.43, P<10⁻⁴; no interaction, F_(17,540)=0.18, not significant (NS). β-adducin KO (b): 8 (home cage) and 11 (NEE) mice per group in 3 experiments; two-way ANOVA: housing effect F_(1,306)=3.76, P=0.053; time factor, F_(17,306)=9.53, P<10⁻⁴; no interaction, F_(17,306)=0.55. (c,d) WT (c) and T75A littermates (d) were treated as in a. WT (c): 10 (home cage) and 11 (NEE) mice per group in 3 experiments; two-way ANOVA: housing factor, F_(1,324)=38.56, P<10⁻⁴; time factor, F_(17,324)=18.38, P<10⁻⁴; interaction, F_(17,324)=1.85, P=0.02. T75A (d): 13 (home cage) and 13 (NEE) mice per group in 3 experiments; two-way ANOVA: housing factor, F_(1,432)=0.40, NS; time factor, F_(17,432)=20.47, P<10⁻⁴; no interaction, F_(17,432)=0.20. (a–d) All data are means±s.e.m. (a,c) Šidák post hoc test for each time bin: *P<0.05; **P<0.01.