Table 1.
p16/Ki-67 positivity by histology and cytology results*
| Cytology result | Total (n = 1509) | No biopsy (n = 288) | Benign (n = 417) | Atypical (n = 62) | CIN1 (n = 567) | CIN2 (n = 76) | CIN3/AIS (n = 92) | Cancer (n = 7) |
|---|---|---|---|---|---|---|---|---|
|
No.
(%) |
No.
(%) |
No.
(%) |
No.
(%) |
No.
(%) |
No.
(%) |
No.
(%) |
No.
(%) |
|
| Negative | 703 (46.59) |
249 (86.46) |
198 (47.48) |
20 (32.26) |
195 (34.39) |
25 (32.89) |
15 (16.30) |
1 (14.29) |
| p16/Ki-67+ | 271 (31.40) |
98 (23.96) |
67 (33.84) |
8 (40.00) |
69 (35.38) |
16 (64.00) |
12 (80.00) |
1 (100.00) |
| ASC-US | 383 (25.38) |
22 (7.64) |
136 (32.61) |
21 (33.87) |
165 (29.10) |
19 (25.00) |
20 (21.74) |
0 (0.00) |
| p16/Ki-67+ | 186 (48.56) |
8 (36.36) |
59 (43.38) |
8 (38.10) |
82 (49.70) |
15 (78.95) |
14 (70.00) |
0 (0.00) |
| LSIL | 319 (21.14) |
15 (5.21) |
65 (15.59) |
18 (29.03) |
181 (31.92) |
22 (28.95) |
17 (18.48) |
1 (14.29) |
| p16/Ki-67+ | 200 (62.70) |
10 (66.67) |
34 (52.31) |
10 (55.56) |
109 (60.22) |
20 (90.91) |
16 (94.12) |
1 (100.00) |
| ASC-H | 36 (2.39) |
1 (0.35) |
8 (1.92) |
1 (1.61) |
16 (2.82) |
5 (6.58) |
5 (5.43) |
0 (0.00) |
| p16/Ki-67+ | 27 (75.00) |
1 (100.00) |
5 (62.50) |
1 (100.00) |
11 (68.75) |
5 (100.00) |
4 (80.00) |
0 (0.00) |
| HSIL | 49 (3.25) |
0 (0.00) |
5 (1.20) |
1 (1.61) |
6 (1.06) |
5 (6.58) |
28 (30.43) |
4 (57.14) |
| p16/Ki-67+ | 45 (91.84) |
0 (0.00) |
4 (80.00) |
1 (100.00) |
5 (83.33) |
4 (80.00) |
27 (96.43) |
4 (100.00) |
| Other | 19 (1.26) |
1 (0.35) |
5 (1.20) |
1 (1.61) |
4 (0.71) |
0 (0.00) |
7 (7.61) |
1 (14.29) |
| p16/Ki-67+ | 14 (73.68) |
1 (100.00) |
4 (80.00) |
1 (100.00) |
1 (25.00) |
0 (0.00) |
6 (85.71) |
1 (100.00) |
| Total | 1,509 (100.0) |
288 (19.09) |
417 (27.63) |
62 (4.11) |
567 (37.57) |
76 (5.04) |
92 (6.10) |
7 (0.46) |
| p16/Ki-67+ | 694 (45.99) |
69 (23.96) |
173 (41.49) |
29 (46.77) |
277 (48.85) |
60 (78.95) |
79 (85.87) |
7 (100.00) |
* P trend % p16/Ki-67+ across cytology categories (excluding Other): P < .001; P trend % p16/Ki-67+ across histology categories (excluding Atypical): P < .001. AIS = cervical adenocarcinoma in situ; ASC-H = atypical squamous cells, cannot rule out high-grade squamous intraepithelial lesion; ASC-US = atypical squamous cells of undetermined significance; CIN = cervical intraepithelial neoplasia; LSIL = low-grade squamous intraepithelial lesions; HSIL = high-grade squamous intraepithelial lesions.