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Molecular pathway underlying interaction of Zn deficiency and miR-31 overexpression in promoting esophageal preneoplasia. Zn deficiency induces miR-31 overexpression, leading to downregulation of its direct target Stk40. Stk40 downregulation activates NF-κB and Rage through S100a8/a9 dimer protein complex, thereby promoting inflammation and cellular proliferation to produce the preneoplastic esophageal phenotype.
